What Is ARA-290?
ARA-290 (Cibinetide) is a synthetic peptide derived from the structure of erythropoietin (EPO), engineered to retain EPO's tissue-protective signaling while eliminating its blood-cell-stimulating (hematopoietic) activity.
Mechanism of Action
ARA-290 selectively activates the innate repair receptor (a complex of the EPO receptor and CD131), a pathway distinct from the classical EPO receptor responsible for red blood cell production, which is why researchers describe it as a non-hematopoietic EPO derivative.
Studied Benefits
These are effects ARA-290 has been studied for in available preclinical and early research — not claims about guaranteed outcomes.
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Neuropathic-Pain Research
ARA-290 has been studied in human clinical trials for neuropathic pain associated with conditions such as sarcoidosis and diabetes, representing one of the more clinically developed compounds in this category.
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Metabolic & Tissue-Protection Research
Beyond pain research, ARA-290 has been studied for effects on metabolic parameters and tissue protection in models of chronic inflammatory conditions, reflecting the innate repair receptor's broader proposed role in cellular stress response.
Dosing Guide
What the research shows
Doses used in published clinical trials are documented in that trial literature and are specific to those regulated study protocols; no FDA-approved commercial dosage exists for ARA-290 research material.
Compound X does not provide dosing recommendations. ARA-290 is sold for laboratory research use only and is not intended for human consumption.
Reported Side Effects
ARA-290/Cibinetide has completed multiple human clinical trials with published safety data indicating it is generally well-tolerated at studied doses; it has not, however, received full FDA approval for a marketed indication, and research-grade material outside those regulated trials has not undergone the same quality controls.
FAQ
Is ARA-290 FDA-approved?
No. ARA-290 is not FDA-approved for any indication and is sold strictly as a research chemical, not a medication or dietary supplement.
What is ARA-290 commonly studied for?
Neuropathic-Pain Research — ARA-290 has been studied in human clinical trials for neuropathic pain associated with conditions such as sarcoidosis and diabetes, representing one of the more clinically developed compounds in this category.
Is ARA-290 legal to buy in the US?
In the US, UK, Canada and Australia, ARA-290 is generally sold labeled "for research use only, not for human consumption." It is not approved as a dietary supplement or medication in any of these countries.
References
ARA-290/Cibinetide clinical trial data is indexed on PubMed under "ARA290 Cibinetide innate repair receptor" and "erythropoietin derivative neuropathic pain."
