Peptides

CJC-1295 (No DAC): Complete Research Guide

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH), engineered for extended stability in circulation compared to native GHRH.

📖 5 min read 🗓️ Updated August 2026 ✍️ Compound X Research Team 🇺🇸 US, UK, CA & AU Sourcing
CJC-1295 (No DAC) research guide cover

🔬 Studied for: GHRH-Pathway Research

💊 Also studied for: Combination Protocol Research

🧪 Not FDA-approved — sold strictly for laboratory research

📈 No standardized human dosage established in published literature

What Is CJC-1295 (No DAC)?

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH), engineered for extended stability in circulation compared to native GHRH. The version most commonly referenced in research without the DAC (drug affinity complex) modifier is closer in half-life to native GHRH and is frequently studied in combination with GH secretagogues like Ipamorelin.

Mechanism of Action

CJC-1295 binds GHRH receptors in the anterior pituitary, stimulating synthesis and release of growth hormone. Research has focused on its modified amino-acid sequence, which confers resistance to enzymatic degradation and produces a more sustained GHRH signal than native GHRH in preclinical models.

Studied Benefits

These are effects CJC-1295 (No DAC) has been studied for in available preclinical and early research — not claims about guaranteed outcomes.

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GHRH-Pathway Research

CJC-1295 is a frequent subject of research examining GHRH receptor signaling and its downstream effects on pulsatile GH and IGF-1 output, often in comparative studies against other GHRH analogs.

Combination Protocol Research

Because GHRH analogs and ghrelin-receptor agonists act on distinct receptors upstream of GH release, CJC-1295 is frequently studied alongside secretagogues such as Ipamorelin to examine potential synergistic effects on GH pulse amplitude.

Dosing Guide

What the research shows

Doses used in preclinical and small clinical research studies vary by study design and are not established as a standardized human protocol. No FDA-approved human dosage exists for CJC-1295.

Compound X does not provide dosing recommendations. CJC-1295 (No DAC) is sold for laboratory research use only and is not intended for human consumption.

Reported Side Effects

CJC-1295 is not FDA-approved for human use and has not completed large-scale controlled human trials. Reported concerns in available literature and anecdotal reports include injection-site reactions and, due to its GH-axis activity, theoretical concerns about insulin sensitivity that have not been fully characterized in long-term human data.

FAQ

Is CJC-1295 (No DAC) FDA-approved?

No. CJC-1295 (No DAC) is not FDA-approved for any indication and is sold strictly as a research chemical, not a medication or dietary supplement.

What is CJC-1295 (No DAC) commonly studied for?

GHRH-Pathway Research — CJC-1295 is a frequent subject of research examining GHRH receptor signaling and its downstream effects on pulsatile GH and IGF-1 output, often in comparative studies against other GHRH analogs.

Is CJC-1295 (No DAC) legal to buy in the US?

In the US, UK, Canada and Australia, CJC-1295 (No DAC) is generally sold labeled "for research use only, not for human consumption." It is not approved as a dietary supplement or medication in any of these countries.

References

CJC-1295 research is indexed on PubMed under search terms such as "CJC-1295 GHRH analog" and "growth hormone releasing hormone modified peptide."

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