Peptides
MOTS-C
MOTS-C is a mitochondrial-derived peptide studied in metabolic and exercise-mimetic research. Below, we compare vendors currently stocking research-grade MOTS-C — not just a single sales page.
MOTS-C is a mitochondrial-derived peptide studied in metabolic and exercise-mimetic research. Below, we compare vendors currently stocking research-grade MOTS-C — not just a single sales page.
Prices and testing claims are pulled from each vendor's product listing. Always confirm current price and COA (Certificate of Analysis) on the vendor's site before buying.
| Vendor | Price | Purity Testing | Code | |
|---|---|---|---|---|
 Amino VaultBest Value |
$59.49 – $203.15 | Third-party COA | Buy Here → | |
 SwissChems |
$69.95 – $699.50 | Third-party COA | Buy Here → | |
 MuscleChem |
£59.99 – £99.99 | In-house testing | Buy Here → | |
 American Peptides |
From $100.00 | Third-party COA | Buy Here → |
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome, discovered in 2015 and classified as a "mitochondrial-derived peptide." It has become a focus of metabolic and exercise-physiology research due to its apparent role in cellular energy regulation.
Research-grade MOTS-c is typically supplied as a lyophilized powder in sealed vials, commonly at 10mg strength, intended for laboratory reconstitution and research use only.
MOTS-c is studied for its ability to translocate to the nucleus under metabolic stress and regulate gene expression via AMPK activation, a pathway central to cellular energy sensing and glucose metabolism in preclinical models.
MOTS-c has been investigated in animal studies for its effects on insulin sensitivity and glucose metabolism, largely through its interaction with the AMPK signaling pathway.
Because circulating MOTS-c levels rise with exercise in some studies, it has been described as an "exercise mimetic" candidate and is studied for its potential role in mitochondrial adaptation to physical activity.
MOTS-c is not FDA-approved and has not completed large-scale human trials. Comprehensive human safety data does not yet exist; reported concerns in early research are limited given how recently the peptide was characterized.
Doses used in the limited existing animal research vary by study design and are not established as a human protocol. No FDA-approved human dosage exists for MOTS-c.
Compound X does not sell MOTS-C directly. We provide independent research, comparisons and vendor links — see the vendor comparison table above for current US, UK, Canada and Australia options.
MOTS-c research is indexed on PubMed under search terms such as "MOTS-c mitochondrial derived peptide" and "MOTS-c AMPK metabolism."
New guides, vendor comparisons and compound breakdowns every week.